Abstract

Sickle cell anaemia is a single point mutation in the globin chain of position 6 resulting from valine replacing glutamic acid leading to sickling and polymerization of the red cells causing the crisis in the patients. The study was done to determine the changes in haematological parameters of sickle cell anaemia patients with osteomyelitis. The study was done in a tertiary hospital in Enugu State, Nigeria. A total of one hundred subjects were recruited for the study (50 subjects were sickle cell anaemia with osteomyelitis and 50 subjects were apparently healthy individuals. The haematological parameters were determined using automation. The results showed decrease in RBC, Haemoglobin, PCV, lymphocytes and increase in WBC and monocytes. The osteomyelitis in the sickle cell anaemia patients could suppress the bone marrow resulting the observed changes in the haematological parameters studied.