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Biomakers of breast cancer: Overview
Author: Emmanuel Ifeanyi Obeagu1,4, Yahye Abdi Ahmed1, Getrude Uzoma Obeagu2, Umi Omar Bunu3, P.C. Ugwu Okechukwu4, Esther U. Alum4,5
Publisher: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN BIOLOGY AND MEDICINE
Published: 2023
Section: School of Allied Health Sciences
Abstract
Breast cancer management depends on biomarkers including estrogen receptor, progesterone receptor, and human
epidermal growth factor receptor 2 (ER/PR/HER2). Though existing scoring systems are widely used and well
validated, they can involve costly preparation and variable interpretation. Additionally, discordances between
histology and expected biomarker findings can prompt repeat testing to address biological, interpretative, or technical
reasons for unexpected results. The levels of these markers can influence how a person with breast cancer is treated in
the clinic.