KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

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2026 School of Public Health

Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post- traumatic stress disorder

Godson Emeka Anyanwu; Ogan Christopher Akanaku; Augustine Oviosun; Precious E. Ekwueme; Paul Anyiom Odey; Chima Paul Okechukwu Ugwu; Chinyere Nkemjika Anyanwu

2026 | Wiley | Pp. 1-13

Background: Post- traumatic stress disorder (PTSD) is a complicated neuropsychiatric disorder that is marked by long- term neuroinflammation, oxidative stress, and poor neuroplasticity in stress- sensitive brain areas. Hesperidin is a citrus- derived flavanon...

2026 Faculty of Biomedical Sciences

Cross-Border Ebola Virus Disease Preparedness in Uganda and the Democratic Republic of the Congo: A Systematic Review of Health Security Capacities, Gaps, and Priorities

Chinyere Nkemjika Anyanwu; Rachelle Soki Marasi; Regina Idu Ejemot-Nwadiaro; Bunu Umi Omar; Theoneste Hakizimana; Nwanganga Ihuoma Ubosi; Zeinab Adam Abakar Mohamed; Chima Paul Okechukwu Ugwu; Emeka Anyanwu

2026 | F1000Research | Pp. 1-25

Background Recurrent Ebola virus disease (EVD) outbreaks in the Democratic Republic of the Congo (DRC) continue to pose substantial cross-border health security risks to neighbouring countries, particularly Uganda. Although numerous preparedness initiatives h...

2026 Faculty of Biomedical Sciences

Antimicrobial stewardship implementation in Western Uganda: a narrative policy and implementation review

Esther Ugo Alum; Bashar Haruna Gulumbe; Friday Ogbu Edeh; Christine Ainebyoona; Daniel Ejim Uti; Okechukwu Paul-Chima Ugwu; Benedict Nnachi Alum; Michael Ben Okon; Patrick Maduabuchi Aja; Vaithiyalingam Subramanian Manjula; Peter Chinedu Agu

2026 | Expert Review of Anti-infective Therapy | Pp. 1-13

Introduction: Antimicrobial resistance (AMR) is a major health-system challenge in Uganda. Western Uganda has documented inappropriate antibiotic prescribing and local resistance patterns, but evidence on routine antimicrobial stewardship (AMS) implementation...

2026 Faculty of Biomedical Sciences

Unlocking the potential of endophytes in enhancing plant secondary metabolite biosynthesis

Esther Ugo Alum; Olisa Alfred Nwuruku; Okechukwu Paul-Chima Ugwu; Daniel Ejim Uti; Simeon Ikechukwu Egba; Darlington Arinze Echegu; Peter Chinedu Agu; Patrick Maduabuchi Aja

2026 | Biochemistry and Biophysics Reports | Pp. 1-10

Plant secondary metabolites (PSMs) are vital bioactive compounds with wide pharmaceutical, agricultural, and industrial applications. However, their commercial production faces challenges due to low yields, environmental variability, and high extraction costs...

2026 Faculty of Biomedical Sciences

Harnessing deep learning for the discovery of latent patterns in multi-omics medical data

Okechukwu Paul-Chima Ugwu; Fabian C. Ogenyi; Chinyere Nkemjika Anyanwu; Melvin Nnaemeka Ugwu; Esther Ugo Alum; Mariam Basajja; Joseph Obiezu Chukwujekwu Ezeonwumelu; Daniel Ejim Uti; Ibe Michael Usman; Chukwuebuka Gabriel Eze; Simeon Ikechukwu Egba

2026 | Medical Data Mining | Pp. 1-14

The rapid growth of biomedical data, particularly multi-omics data including genomes,transcriptomics, proteomics, metabolomics, and epigenomics, medical research and clinicaldecision-making confront both new opportunities and obstacles. The huge and diversifi...

2026 Faculty of Biomedical Sciences

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia- Induced Glycolysis by Targeting Hypoxia- Inducible Factor- 1 Alpha and Downstream Metabolites

Daniel Ejim Uti; Wilson Achu Omang; Esther Ugo Alum; Inalegwu Bawa; Okechukwu Paul-Chima Ugwu; Ayodeji Oluwafemi Idowu; Item Justin Atangwho; Godwin Eneji Egbung

2026 | Cancer Medicine | Pp. 1-23

Background: Prostate cancer (PCa) is a major cause of cancer- associated death in men. A crucial factor in its development and treatment resistance is tumor hypoxia, which drives metabolic reprogramming (especially reconfiguration towards glycolysis), mediate...

2026 School of Allied Health Sciences

Comparative Effectiveness of DHIS2 and FAIR Data Approaches for Privacy-Preserving Health Data Analytics in Uganda: A Systematic Review

Mariam Basajja; Ugwu Okechukwu Paul-Chima

2026 | Dove Press | Pp. 1-16

Purpose: Uganda’s digital health transformation anchored on District Health Information Software 2 (DHIS2) and the FAIR (Findable, Accessible, Interoperable, Reusable) Data Principles has reshaped health data governance. Nevertheless, systemic constraints in...

2026 Faculty of Biomedical Sciences

Gas Chromatography-Mass spectrometry (GC-MS) Revealed Bioactive Constituents of Brassica oleracea var. viridis (Collard Greens) Used to Treat Male Infertility in Uganda.

Emmanuel Orire Ikuomola; Daniel Udofia Owu; Victor Otu Oka; Sunday Agba Bisong; Ugwu Okechukwu Paul-Chima; Patrick Maduabuchi Aja

2026 | F1000Research | Pp. 1-27

Background Medicinal plants play a crucial role in pharmacological research, as many pharmaceutical companies rely on them for raw materials. Collard greens, also known as “Sukuma wiki,” are a member of the Brassica oleracea var. viridis family and are known...

2026 Faculty of Biomedical Sciences

Neuro-entero-cardiac bridge: could gut-derived catecholamine-loaded extracellular vesicles synchronize the pathogenesis of Parkinson’s disease, irritable bowel syndrome, and stress-triggered arrhythmias?

Okechukwu Paul-Chima Ugwu; Mariam Basajja; Fabian C. Ogenyi; Chinyere N. Ugwu; Michael Ben Okon; Mustafa M. Mundu

2026 | Medical Hypotheses | Pp. 1-4

The gut–brain–heart axis is increasingly recognized as a clinically relevant interface in chronic and stress- responsive disorders. Parkinson’s disease (PD), irritable bowel syndrome (IBS), and stress-triggered arrhythmias show epidemiologic and mechanistic c...

2026 Faculty of Biomedical Sciences

Next-generation strategies against prostate cancer: natural products and nanomedicine targeting prostate cancer stem cells

Daniel Ejim Uti; Wilson Achu Omang; Esther Ugo Alum; Inalegwu Bawa; Okechukwu Paul-Chima Ugwu; Simeon Ikechukwu Egba

2026 | Journal of Men's Health | Pp. 1-21

AbstractRecurrence, metastasis, and treatment resistance are significant issues in prostate cancermanagement. Evidence increasingly substantiates the notion that prostate cancer stemcells (PCSCs) initiate cancer, facilitate its progression, and complicate the...