KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

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2026 Faculty of Biomedical Sciences

Hydrogen sulfide as a therapeutic gas: challenges and opportunities in precision medicine

Okechukwu Paul-Chima Ugwu; Esther Ugo Alum; Val Hyginus Udoka Eze; Basajja Mariam

2026 | Medical Gas Research | Pp. 1-2

Hydrogen sulfide (H₂S) was once considered a toxic environmental pollutant, but scientific thinking has shifted, and it is now recognized as the third endogenous gasotransmitter, alongside nitric oxide and carbon monoxide.1 This transition to a central signal...

2026 Faculty of Biomedical Sciences

RNA-protein complexes as key regulators of plant secondary metabolism: Biophysical interactions and functional significance

Okechukwu Paul-Chima Ugwu; Melvin Nnaemeka Ugwu; Hilal Ahmad Rather; Hope Onohuean; Ibe Michael Usman

2026 | Biochemistry and Biophysics Reports | Pp. 1-15

RNA-protein complexes (RNPs) are central regulators of post-transcriptional gene expression and are increasingly implicated in controlling when, where and to what extent specialised (secondary) metabolic pathways operate in plants. Relative to transcription f...

2026 Faculty of Biomedical Sciences

Berberine attenuates SPS-induced cognitive and affective deficits and corticolimbic injury in Wistar rats via restoration of BDNF and redox inflammatory balance

Godson Emeka Anyanwu, Precious E. Ekwueme, Ayugha Nsan, Lilian Ezeugwu, Prisca Chiamaka Ogbe, Chinyere N. Anyanwu, Vivian O. Ojiakor & Chima Paul Okechukwu Ugwu

2026 | Nutritional Neuroscience

Background:Single prolonged stress (SPS) is a validated PTSD-like paradigm that causes cognitive and affective dysfunction and corticolimbic injuries due to the dysregulation of the HPA-axis and neurotrophic, redox, and neuroimmune pathways. Berberine is a bi...

2026 Faculty of Clinical Medicine and Dentistry

Evidence on Genitourinary Syndrome of Menopause in Africa: A Systematic Review and Narrative Synthesis of Symptom Based Studies and Care Gaps

Rihaam Abshir Ali; Theoneste Hakizimana; Musa Kasujja; Maxwell Okello; Emmanuel Okurut; Chinyere Nkemjika Anyanwu; Chima Paul Okechukwu Ugwu; Michael Ben Okon; EMEKA ANYANWU

2026 | Open Research Africa | Pp. 1-17

Background Genitourinary syndrome of menopause (GSM) encompasses a spectrum of vulvovaginal, sexual, and urinary symptoms associated with estrogen deficiency and is increasingly recognized as a major contributor to morbidity among midlife and older women. Whi...

2026 School of Engineering and Applied Sciences

Advancing controlled environment urban agriculture: integrating LED spectral engineering and intelligent nutrient delivery systems for optimized growth across diverse crop species

Chinyere Nneoma Ugwu; Okechukwu Paul-Chima Ugwu; Jovita Nnenna Ugwu

2026 | Frontiers in Horticulture | Pp. 1-21

Urban controlled-environment agriculture (CEA) has emerged as a technologicallyadvanced approach to food production that seeks to address land scarcity, climateinstability, and the growing demand for fresh produce in cities. This reviewexamined the role of sm...

2026 School of Allied Health Sciences

Workplace stress: prevalence, sources, and consequences among academic staff at the University of Calabar, Nigeria

Regina Idu Ejemot-Nwadiaro; Nuria Sylvanus Nwachuku; Eucharia Obiageli Obiekezie; Joshua Pam Mwankon; Elizabeth Libuo-Beshel Nji; Peter Bassey Enyievi; Okechukwu Paul-Chima Ugwu

2026 | Frontiers in Public Health | Pp. 1-10

Background: Workplace stress among university academics in sub-Saharan Africa remains insufficiently investigated, particularly in studies that combine validated psychometric assessment with objective clinical measurements and evaluation of stress-related lif...

2026 Faculty of Biomedical Sciences

Reproductive tract microbiota and anatomical integrity: implications for fertility, pregnancy, and neonatal outcomes: a narrative review

Chinyere Nkemjika Anyanwu; Paul Chima Ugwu Okechukwu; Dominic Terkimbi Swase; Michael Ben Okon; Regan Mujinya; Moses Thembo; Emeka Godson Anyanwu

2026 | Middle East Fertility Society Journal | Pp. 1-18

Background The microbiota of the reproductive system is a vital factor in fertility, pregnancy and neonatal health. Microbiota composition may control implantation, gestational preservation and neonatal colonization. The vaginal, cervical and uterine/endometr...

2026 Faculty of Biomedical Sciences

Nano-enhanced phytomedicine: A review of nanocarrier systems for targeted delivery of plant-derived bioactives in chronic disease therapy

Okechukwu Paul-Chima Ugwu; Melvin Nnaemeka Ugwu; Fabian C. Ogenyi; Val Hyginus Udoka Eze; Mariam Basajja; Jovita Nnenna Ugwu; Michael Ben Okon; Chinyere N. Ugwu; Samanya Bulhan; Darlington Arinze Echegu; Jude Uchechukwu Aleke

2026 | Phytomedicine Plus | Pp. 1-11

Background/objectives: Chronic diseases such as cancer, diabetes, neurodegenerative disorders, and cardiovascular diseases continue to pose significant global health challenges. Phytomedicine offers therapeutic potential through antioxidant, anti-inflammatory...

2026 Faculty of Biomedical Sciences

Tr ansgener ational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review

Okon Michael Ben; Olorunnisola Sinbad Olubukola; Ifie Josiah Eseoghene; Ugwu Okechukwu Paul-Chima; Alum Esther Ugo; Mounmbegna Philippe; Aja Patrick Maduabuchi

2026 | Environmental Epigenetics | Pp. 1-13

Bisphenol A (BPA), which is a common ingredient of plastics and epoxy resins, is among the most commonly found endocrine-disrupting chemicals in the human envir onment. Chr onic human e xposur e has raised concerns over its effects on reproductive health. The...

2026 Faculty of Biomedical Sciences

Nanoparticle-mediated mRNA delivery for cancer, autoimmunity, and genetic diseases: a rapid review

Okechukwu Paul-Chima Ugwu; Fabian C. Ogenyi; Mariam Basajja; Chinyere N. Ugwu; Mundu M. Mustafa; Michael Ben Okon

2026 | Frontiers in Drug Delivery | Pp. 1-12

Introduction: Messenger RNA (mRNA) therapeutics have advanced from experimental platforms to clinical application, driven largely by the success of lipid nanoparticle (LNP)-based COVID-19 vaccines. Building on this progress, nanoparticle-mediated mRNA deliver...