KIU Publications

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2026 Faculty of Biomedical Sciences

Exploring the use of phytotherapy in benign prostatic hyperplasia [BPH]: a systematic review

Herbert Mbyemeire; Ilemobayo Victor Fasogbon; Angela Mumbua Musyoka; Augustine Oviosun; Vivian Onyinye Ojiakor; Mary Olaoluwa Agunloye; Wusa Makena; Micheal Ben Okon; Emmanuel O. Ikuomola; Reuben Samson Dangana 1, Ibe Micheal Usman; Ekom Monday Etukudo; Swase Dominic Terkimbi; Comfort Vandu Danchal; Regan Mujinya; Solomon A Mbina; Idara Asuquo Okon; Esther Ugo Alum; Ibrahim Babangida Abubaka; Nancy B. Mitaki; Godson Emeka Anyanwu; Okechukwu Paul-Chima Ugwu; Sanusi Ahmed Jega; Daniel Ejim Uti; Lucy Aja; Elna Owembabazi; Stellamaris Kembabazi; Agu Peter Chinedu; Olubukola Sinbad Olorunnisola; Patrick Maduabuchi Aja

2026 | F1000Research | Pp. 1-43

Background Benign prostatic hyperplasia [BPH] is a prevalent condition among aging men, characterized by prostate gland enlargement leading to lower urinary tract symptoms [LUTS]. Conventional treatments like alpha-blockers and 5-alpha-reductase inhibitors, t...

2026 Faculty of Biomedical Sciences

Noncoding RNAs and the phytochemical economy: Molecular regulators of secondary metabolism in medicinal plants

Okechukwu Paul-Chima Ugwu; Melvin Nnaaemeka Ugwu; Ibe Michael Usman; Hilal Ahmad Rather;

2026 | Biochemistry and Biophysics Reports | Pp. 1-13

Background: Medicinal plants produce specialised (secondary) metabolites including alkaloids, terpenoids, flavonoids and phenolics that underpin pharmaceuticals, nutraceuticals and traditional therapeutics. Although enzyme-encoding genes and transcription fac...

2026 Faculty of Biomedical Sciences

Plant and soil-derived polyphenols shape soil microbiomes and crop outcomes: a systematic review and meta-analysis.

Okechukwu Paul-Chima Ugwu; Fabian C. Ogenyi; Esther Ugo Alum; Mariam Basajja; Jovita Nnenna Ugwu; Chinyere N. Ugwu; Regina Idu Ejemot-Nwadiaro; Michael Ben Okon; Uti Daniel Ejim; Mundu M. Mustafa; Ashiru Muhammad; Fadia Ahmed Abdelkader Reshia

2026 | Frontiers in Soil Science | Pp. 1-11

Background: Polyphenols from root exudates and polyphenol-rich organic inputs may shape soil microbiomes, enzyme activities, and crop nutrient outcomes, with relevance to regenerative agriculture. Objectives: To quantify the effects of plant- and soil-derived...

2026 Faculty of Biomedical Sciences

Medicinal Plants and the Gastrointestinal Microbiota in Chronic Diseases Modulation: A Structured Mechanistic and Translational Review

Esther Ugo Alum; Daniel Ejim Uti; Okechukwu Paul-Chima Ugwu; Michael Ben Okon; Waheeb Sami Aggad; Hailah M. Almohaimeed; Neeraj Bainsal; Sandeep Kumar Shukla; Kranti Kiran Reddy Ealla

2026 | Current Microbiology | Pp. 1-19

The gut microbiome supports digestion, immunity, and metabolism; its imbalance (dysbiosis) drives inflammation and metabolic dysfunction, contributing to chronic diseases such as diabetes, cardiovascular disease, inflammatory bowel disease, and autoimmune dis...

2026 Faculty of Science and Technology

The Internet of Plants: Re-Imagining Plant Signalling Networks Through an Information-and-Communication Theory Lens

Esther Ugo Alum; Vaithiyalingam Subramanian Manjula; Okechukwu Paul-Chima Ugwu; Daniel Ejim Uti;, Benedict Nnachi Alum; Darlington Arinze Echegu

2026 | Sage | Pp. 1-11

Abstract1,3, and Plants are dynamic, responsive systems capable of perceiving, integrating, and transmitting information across multiple scales, from molecular pathways within cells to complex interactions at the community level. Emerging evidence demonstrate...

2026 School of Engineering and Applied Sciences

Digital twins for food processing and shelf-life: linking mechanistic models, sensors, and AI to predict quality, safety, and waste through near-real-time decision support

Chinyere Nneoma Ugwu; Fabian Chukwudi Ogenyi; Okechukwu Paul-Chima Ugwu; Jovita Nnenna Ugwu; Micheal Ben Okon

2026 | Frontiers in Food Science and Technology | Pp. 1-18

Hybrid digital twins (DTs) are emerging as decision-support systems for perishable food supply chains because they can transform shipment-specific exposure histories into individualized forecasts of quality evolution, safety risk, and remaining shelf-life (RS...

2026 Faculty of Biomedical Sciences

Nanotechnology-enabled targeted delivery of incretin therapies for the treatment of obesity and metabolic disorders

Daniel Ejim Uti; Samuel Ali Agada; Josephine E. Egbung; Celestine O. Ogbu; Esther Ugo Alum; Inalegwu Bawa , Okechukwu Paul-Chima Ugwu

2026 | Obesity Medicine | Pp. 1-23

Obesity is a significant health issue worldwide, and a key risk factor for type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), non-alcoholic fatty liver disease (NAFLD), and related complications. Incretin-based therapies, especially glucagon-like...

2026 School of Pharmacy

Synergistic phytochemicals in multi-target drug discovery for complex diseases: A narrative review

Okechukwu Paul-Chima Ugwu; Melvin Nnaemeka Ugwu; Fabian C. Ogenyi; Esther Ugo Alum; Val Hyginus Udoka Eze; Mariam Basajja; Jovita Nnenna Ugwu; Michael Ben Okon; Chinyere N. Ugwu; Chinyere Nkemjika Anyanwu; Joseph Obiezu Chukwujekwu Ezeonwumelu; Dominic Terkimbi Swase; Bulhan Samanya; Simeon Ikechukwu Egba; Daniel Ejim Uti; Hope Onohuean

2026 | Phytomedicine Plus | Pp. 1-13

Background/problem statement: Single-target pharmaceutical treatments generally fail to address the complex pathophysiology of chronic illnesses such as cancer, cardiovascular disorders, diabetes, and neurodegeneration. These conditions are prone to medicatio...

2026 Faculty of Biomedical Sciences

T Helper Cells and Cytokine Networks in the Immunopathogenesis of Multiple Sclerosis

Simeon Ikechukwu Egba; Gavin Chibundu Ikechukwu Innocent Ogheneovo Orhonigbe; Chinenye Iheanyi Okereke; Robert Ikechukwu Uroko; Okechukwu Paul Chima Ugwu

2026 | Dove Press | Pp. 1-21

Abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder of CNS with demyelination, neurodegeneration and compartmentalized inflammatory disorder. Excessive T-helper cell (CD4+) activation and unregulated cytokine signaling play a key role in its on...

2026 School of Pharmacy

Nanotechnology-enabled modulation of reactive oxygen species in cancer and chronic inflammation: a systematic review of therapeutic advances and translational challenges

Ugwu Okechukwu Paul-Chima; Ogenyi Fabian Chukwudi; Alum Esther Ugo; Mariam Basajja; Ugwu Jovita Nnenna; Ugwu Chinyere Nneoma; Ejemot-Nwadiaro Regina Idu; Mundu M. Mustafa; Okon Michael Ben; Uti Daniel Ejim; Ashiru Muhammad; Fadia Ahmed Abdelkader Reshia

2026 | Discover Nano | Pp. 1-31

Background Reactive oxygen species (ROS) are key regulators of cellular signalling and homeostasis, but if not managed, they can cause genomic instability, activation of carcinogenic pathways, and chronic inflammation. Approaches to ROS regulation using nanot...