KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

Scholarly Work

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2026 School of Pharmacy

Long-Acting Cabotegravir ONLINE ISSN: 1115- 6198 Print ISSN: 1597-3107 Injectable Pre-Exposure Prophylaxis: Efficacy and Implementation in High-Risk Populations

Wotsomu Evasi

2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 31-37

Human immunodeficiency virus (HIV) remained a global public health challenge despite advances in antiretroviral therapy. Oral pre-exposure prophylaxis with tenofovir-based regimens has demonstrated efficacy but faces adherence barriers that limit real-world e...

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2026 School of Pharmacy

Long-Acting Cabotegravir for Pre-Exposure Prophylaxis: Efficacy, Implementation, and Global Access

Wotsomu Evasi

2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 24-30

Human immunodeficiency virus pre-exposure prophylaxis had traditionally relied on daily oral tenofovir-based regimens, which demonstrated high efficacy when adherence is maintained but face substantial implementation challenges related to daily pill burden, s...

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2026 School of Pharmacy

Lipid-Based Nanocarriers for Targeted Delivery to Pancreatic β-Cells in Obese Diabetic Models

Nantulya Morris Francis

2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 9-17

Obesity-linked type 2 diabetes is driven by chronic insulin resistance coupled to progressive dysfunction and loss of pancreatic β-cells. Standard glucose-lowering therapies improve glycemia but either protect β-cells only indirectly or require high systemic...

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2026 Faculty of Biomedical Sciences

Lipid-Based Nanocarriers for Modulating Adipogenesis and Lipid Metabolism: Emerging Anti-Obesity Strategies

Bwambale Isaac

2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 1-8

Obesity is characterized by chronic energy surplus, hypertrophic and hyperplastic expansion of white adipose tissue, ectopic lipid deposition and complex disturbances in lipid and glucose metabolism. Pharmacologic approaches that directly modulate adipogenesi...

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2026 School of Pharmacy

Lipid-Based Nanocarriers for Dual Modulation of Lipid Metabolism and Glucose Homeostasis

Wotsomu Evasi

2026 | RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES | Pp. 18-23

Lipid metabolism and glucose homeostasis are two intertwined metabolic processes that are often dysregulated in conditions such as obesity, insulin resistance, and type 2 diabetes (T2D). Given the complexity of these disorders, therapeutic strategies targetin...

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2026 School of Pharmacy

Interplay Between Oxidative Stress and Inflammatory Pathways in Malaria, Diabetes, and Arthritis: Implications for Novel Therapeutic Targets

Kabazzi Douglas T.

2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 109-113

Oxidative stress and inflammation are interconnected biological processes that underlie the pathogenesis of many chronic and infectious diseases. In malaria, diabetes, and arthritis, the imbalance between reactive oxygen species (ROS) generation and antioxida...

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2026 School of Pharmacy

Inter-Organ Lipid Trafficking in Obesity-Induced Diabetes: From Adipose Overflow to Lipotoxic Organ Crosstalk

Kabazzi Douglas T.

2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 101-108

Obesity-induced type 2 diabetes (T2D) is not simply a problem of “too much fat” but of where lipid ends up and how it moves between organs. Under physiological conditions, subcutaneous adipose tissue (AT) serves as a safe reservoir that buffers postprandial l...

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2026 School of Pharmacy

Integrative Approaches in Reducing Steroid Dependency: Exploring Alternative Therapies for Chronic Inflammatory Conditions

Omagor Jacob

2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 97-100

Chronic inflammatory conditions such as rheumatoid arthritis, lupus, and asthma often require long-term management with corticosteroids to control inflammation and prevent tissue damage. However, the prolonged use of steroids is associated with numerous adver...

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2026 School of Pharmacy

Integrating Whole-Genome Sequencing with Social Determinants Data for Coronary Artery Disease Risk Prediction: Interpretability, Bias, and Real-World Performance, Implementation, and Equity Considerations

Namirimu Sandrah

2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 86-96

Coronary artery disease (CAD) remains the leading cause of morbidity and mortality globally. While traditional risk prediction models rely on clinical, biochemical, and demographic factors, they often omit the contribution of genetic variation and social dete...

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2026 School of Pharmacy

Integrating Traditional and Modern Medicine in Diarrhea Control: Cultural Sensitivity and Future Perspectives in Africa

Namirimu Sandrah

2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 81-85

Diarrheal diseases remain a significant public health issue in Africa, causing considerable morbidity and mortality, particularly among children under five years old. In addressing this challenge, the integration of traditional and modern medicine presents a...

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