Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.
Scholarly Work
Search peer-reviewed articles, reports, books, policy briefs and other scholarly outputs by KIU researchers and collaborators.
2026 | RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES | Pp. 1-7
Despite effective antiretroviral therapy, people living with HIV harbored a latent viral reservoir in long-lived memory CD4+ T cells that prevents cure. Immune checkpoint molecules, initially recognized for their role in maintaining peripheral tolerance and p...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 102-110
Human immunodeficiency virus (HIV) persisted in latent reservoirs despite effective antiretroviral therapy (ART), presenting the primary barrier to achieving a functional cure. Immune checkpoint inhibitors (ICIs), originally developed for cancer immunotherapy...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 31-37
Severe malaria, predominantly caused by Plasmodium falciparum, progresses unpredictably from uncomplicated infection to life-threatening complications, including cerebral malaria, severe anemia, and metabolic acidosis. Immune responses varied substantially be...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 94-101
Plasmodium infection triggered profound alterations in host metabolic pathways affecting glucose metabolism, lipid homeostasis, amino acid catabolism, and mitochondrial function across multiple organ systems. These metabolic perturbations represented adaptive...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 87-93
Plasmodium falciparum infection triggered complex host immune responses that determined disease severity, with cerebral malaria representing the most lethal complication characterized by profound neuroinflammation, endothelial dysfunction, and blood-brain bar...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 38-42
Type 2 diabetes mellitus (T2DM) was characterized by impaired glucose homeostasis and insulin resistance, necessitating pharmacologic interventions to maintain glycemic control. Sulfonylureas (SUs) had been widely used to stimulate insulin secretion but were...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 8-12
Metabolic disorders such as diabetes mellitus are frequently associated with serious hepatic and renal complications that contribute significantly to morbidity and mortality. The underlying mechanisms involve complex interactions among hyperglycemia, dyslipid...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 63-67
Whole-genome sequencing (WGS) has rapidly transitioned from specialized research laboratories to the direct-toconsumer (DTC) genetic testing marketplace due to declining costs and advances in high-throughput sequencing technologies. While these services expan...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 43-52
Whole-exome sequencing (WES) in biobank initiatives has emerged as a transformative tool for advancing genomic research and precision medicine. By capturing all protein-coding regions of the human genome, WES enables the identification of genetic variants tha...
2026 | RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES | Pp. 21-30
Single-cell transcriptomics is emerging as a powerful tool for public health surveillance, enabling high-resolution detection of pathogen activity, host responses, and environmental biological signals at unprecedented spatial and temporal scales. While this t...