KIU Publications

Research outputs, reports, policy briefs and knowledge products from KIU scholars and partners.

Scholarly Work

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2026 Faculty of Biomedical Sciences

Redefining feed efficiency through the livestock gut microbiome

Matthew Chidozie Ogwu, Sylvester Chibueze Izah, Esther Ugo Alum, Olugbemiga Ojo Aliu, Morufu Olalekan Raimi and Ayebapreye Kari

2026 | Frontiers in Physiology | Pp. 1-11

Feed efficiency remains a central goal in livestock production because it determines both economic viability and environmental performance. Yet conventionalmeasures such as feed conversion ratio and residual feed intake often treatefficiency as a host-level o...

2026 Faculty of Biomedical Sciences

Nanotechnology-enabled modulation of reactive oxygen species in cancer and chronic inflammation: a systematic review of therapeutic advances and translational challenges

Ugwu Okechukwu Paul-Chima, Ogenyi Fabian Chukwudi, Alum Esther Ugo, Mariam Basajja, Ugwu Jovita Nnenna, Ugwu Chinyere Nneoma, Ejemot-Nwadiaro Regina Idu3, Mundu M. Mustafa, Okon Michael Ben, Uti Daniel Ejim, Ashiru Muhammad and Fadia Ahmed Abdelkader Reshia

2026 | Discover Nano | Pp. 1-31

Background Reactive oxygen species (ROS) are key regulators of cellular signalling and homeostasis, but if not managed, they can cause genomic instability, activation of carcinogenic pathways, and chronic inflammation. Approaches to ROS regulation using nanot...

2026 Faculty of Biomedical Sciences

Microfluidic nanochips for rapid exosome isolation and multiplex biomarker profiling from a single blood drop: Toward sample-to-answer liquid biopsy

Daniel Ejim Uti, EstherUgoAlum, JosephineE.Egbung, Waheeb Sami Aggad, HailahM.Almohaimeed, ZuhairM.Mohammedsaleh, Manpreet Kaur, Kranti KiranReddy Ealla

2026 | Wiley | Pp. 1-34

Background: Exosomes and other small extracellular vesicles carry molecular cargo that can reflect disease status, therapeutic response, and relapse dynamics. Currently, most exosome-analysis workflows are centralized, require milliliter sized blood samples,...

2026 School of Allied Health Sciences

Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers in Sub- Saharan Africa: A Critical Review of Clinical Evidence, Health- System Feasibility and Public Health Implications

Matthew Chibunna Igwe, Esther Ugo Alum, Alphonsus Ogbonna Ogbuabor, Yibala Ibor Oboma, Onyinyechi Bede-Ojimadu, Charles Iyore Idehen

2026 | Wiley | Pp. 1-16

Diabetic foot ulcers are an important cause of morbidity, amputation, disability and healthcare expenditure in sub- Saharan Africa, where limitations in preventive foot care, referral pathways, vascular services, multidisciplinary wound care and financial pro...

2026 Faculty of Clinical Medicine and Dentistry

Food Sovereignty and Agroecology in Conflict Zones: Building Resilience Amidst Crisis

Esther Ugo Alum, Daniel Ejim Uti, Ainebyoona Christine, Sylvester Chibueze Izah, Matthew Chidozie Ogwu, Chukwuoyims Kevin Egwu, Richard Obinna Alum, Rasiravathanahalli Kaveriyappan Govindarajan

2026 | Wiley | Pp. 1-27

Armed conflict disrupts agricultural production, displaces farming communities, degrades natural resources, and weakens local institutions, thereby intensifying food insecurity and dependence on humanitarian assistance. This review examined how food sovereign...

2026 Faculty of Biomedical Sciences

Exosome-loaded nanoradiosensitizers in radiotherapy for preventing post-irradiation tumor recurrence: mechanisms, preclinical evidence, and translational challenges

Daniel Ejim Uti, Josephine E. Egbung, Bassey Omeh Anthony, Ogar Rose Omari, Wilson Achu Omang, Waheeb Sami Aggad, Hailah M. Almohaimeed, Neeraj Bainsal, Sandeep Kumar Shukla, Kranti Kiran Reddy Ealla and Esther Ugo Alum

2026 | Discover Nano | Pp. 1-34

Radiotherapy remains a cornerstone in cancer treatment, yet its therapeutic efficacy is often limited by radioresistance, tumor heterogeneity, and recurrence post-irradiation. Nanotechnology has emerged as a promising avenue to enhance radiosensitization, imp...

2026 Faculty of Biomedical Sciences

Ethanolic extract of Cnidoscolus aconitifolius leaves alleviates insulin resistance by modulating oxidative stress and inflammation in albino rats exposed to heavy metal mixture

Uche Obasi Orji, Udu Ama Ibiam, Joshua Nonso Awoke, Ayomide Victor Atoki, Ejike Daniel Eze, Otuomasiri Divine Obasi, Celestine Ogbu, Nkiru Nwamaka Ezeani, Esther Ugo Alum, Chinyere Aloke, Daniel Etim Uti & Patrick Maduabuchi Aja

2026 | Natural Product Research | Pp. 3629-3642

Exposure to heavy metals significantly contributes to insulin resistance, a major factor in type 2 diabetes. This study investigated the antioxidant and therapeutic potential of ethanol leaf extract of Cnidoscolus aconitifolius in mitigating heavy metal-induc...

2026 Faculty of Biomedical Sciences

A systematic review on the sources and health risk of heavy metal contamination in environmental and food systems in Uganda

Sandra Omo Etumah Ifie, Boniface Anthony Ale, Ilemobayo Victor Fasogbon, Ekom Monday Etukudo, Angela Mumbua Musyoka, Vivian Onyinye Ojiakor, Wusa Makena, Emmanuel O. Ikuomola, Reuben Samson Dangana, Nancy B. Mitaki, Ibe Micheal Usman, Augustine Oviosun, Regan Mujinya, Elizabeth B. Umoren, Solomon A. Mbina, Esther Ugo Alum, Ibrahim Babangida Abubarkar, Robert Siida1, Swase Dominic Terkimbi, Josiah Eseoghene Ifie, Saidi Odoma and Patrick Maduabuchi Aja

2026 | Discover Environment | Pp. 1-26

This study systematically reviewed research on heavy metal contamination in environmental and food systems in Uganda using the PRISMA 2020 data reporting method and the PICOS framework. An extensive literature search of published papers on heavy metal contami...

2026 Faculty of Biomedical Sciences

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia- Induced Glycolysis by Targeting Hypoxia- Inducible Factor- 1 Alpha and Downstream Metabolites

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Inalegwu Bawa, Okechukwu Paul-Chima Ugwu, Ayodeji Oluwafemi Idowu, Item Justin Atangwho, Godwin Eneji Egbung

2026 | Cancer Medicine | Pp. 1-25

Background: Prostate cancer (PCa) is a major cause of cancer- associated death in men. A crucial factor in its development and treatment resistance is tumor hypoxia, which drives metabolic reprogramming (especially reconfiguration towards glycolysis), mediate...

2026 Faculty of Biomedical Sciences

Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Okechukwu Paul-Chima Ugwu, Margaret Amieibi Wokoma, Rowland Inalegwu Oplekwu, Item Justin Atangwho and Godwin Eneji Egbung

2026 | Nutrition and Metabolic Insights | Pp. 1-29

Obesity is a complex metabolic disorder associated with chronic low-grade inflammation, insulin resistance, and heightened risk of comorbidities such as cardiovascular diseases and type 2 diabetes mellitus (T2DM). The Cluster of Differentiation 44 (CD44), a t...